| Pair Name | Tanshinone IIA, Aurora kinase inhibitor | ||
| Phytochemical Name | Tanshinone IIA (PubChem CID: 164676 ) | ||
| Anticancer drug Name | Aurora kinase inhibitor (PubChem CID: / ) | ||
| Structure of Phytochemical |
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MOL
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| Structure of Anticancer Drug |
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| Pair Name | Tanshinone IIA, Aurora kinase inhibitor | |||
| Disease Info | [ICD-11: 2B66.0] | Oral squamous cell carcinoma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Down-regulation | Phosphorylation | AURKB | hsa9212 |
| Down-regulation | Phosphorylation | H3C1 | hsa8350 | |
| In Vitro Model | SCC-9 | Tongue squamous cell carcinoma | Homo sapiens (Human) | CVCL_1685 |
| SCC-15 | Tongue squamous cell carcinoma | Homo sapiens (Human) | CVCL_1681 | |
| SCC-25 | Tongue squamous cell carcinoma | Homo sapiens (Human) | CVCL_1682 | |
| CAL-27 | Tongue adenosquamous carcinoma | Homo sapiens (Human) | CVCL_1107 | |
| In Vivo Model | The OSCC xenograft models were constructed by s.c. injection of CAL27 (2×10⁶) or SCC25 (3×10⁶) cells into the right flank of 6-week-old athymic nude mice (n = 5). | |||
| Result | Targeting Aurora B kinase with Tanshinone IIA suppresses tumor growth and overcomes radioresistance | |||
| No. | Title | Href |
|---|---|---|
| 1 | Targeting Aurora B kinase with Tanshinone IIA suppresses tumor growth and overcomes radioresistance. Cell Death Dis. 2021 Feb 4;12(2):152. doi: 10.1038/s41419-021-03434-z. | Click |
